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Ketoconazole can cause elevated plasma concentrations of selected drugs metabolized via CYP3A4 which may prolong the QT interval, sometimes resulting in life-threatening ventricular arrhythmias such as torsade de pointes

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Shortening of DNA molecules was evident as untreated samples contained high counts of molecules in the 40-80 m range, while samples treated with Cu 3 -TC-Py and nitrofurantoin contained limited numbers of molecules above 40 m and a significantly increased density of molecules below 20 m